Sedating antihistamines side effects
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Dependency, Withdrawal Symptoms, and Rebound Insomnia. The risk for rebound insomnia, dependence, and tolerance is lower with non-benzodiazepine hypnotics than with benzodiazepine drugs. In any case, no hypnotic should be taken for more than 7 - 10 days or at higher than the recommended dose without a doctor's approval.Benzodiazepines used to be the most commonly prescribed sedative hypnotics.
They should not be used at the same time as medications that prevent nausea or motion sickness.
Both benzodiazepine and non-benzodiazepine sedative hypnotics act on GABA-A receptor sites in the brain, but non-benzodiazepines are more specific in the subunits they target.
Developed in the late 1980s, these drugs are now the preferred sedative hypnotic drugs for the treatment of insomnia.
Diphenhydramine is the most common antihistamine used non-prescription sleep aids. Certain antihistamines indicated only for allergies, such as chlorpheniramine (Chlor-Trimeton), diphenhydramine (Benadryl), or hydroxyzine (Atarax or Vistaril) may also be used as mild sleep-inducers.
Some drugs contain diphenhydramine alone (such as Nytol, Sleep-Eez, and Sominex), while others contain combinations of diphenhydramine with pain relievers (such as Anacin P. Unfortunately, most of these drugs leave patients feeling drowsy the next day and may not be very effective in providing restful sleep.
Antidepressants are sometimes used to treat insomnia that may be caused by depression (secondary insomnia).
In addition, some antidepressants with sedating properties are prescribed for the treatment of primary insomnia.These drugs include benzodiazepines and non-benzodiazepines. Sedative hypnotics carry risks for withdrawal, dependency, and rebound insomnia.The chance of risk for these problems varies among different drugs. Many over-the-counter sleeping medications use antihistamines, which cause drowsiness. Doxylamine (Unison) is another antihistamine used in sleep medications.In general, these drugs are recommended for short-term use (7 - 10 days), and treatment should not exceed 4 weeks. Non-benzodiazepine hypnotics currently approved in the United States are: zolpidem Side Effects.All of these drugs have fewer morning side effects than the benzodiazepines, including morning sedation and memory loss (although they can occur to some degree).Care should be taken in the use of trazodone and other sedating antidepressants in elderly patients, due to the risk for side effects (daytime sleepiness, dizziness, and priapism) and drug interactions.