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Changes in the sexual desires of any partner in a sexual relationship, if sustained and unresolved, may cause problems in the relationship.The infidelity of a partner may be an indication that a partner's changing sexual desires can no longer be satisfied within the current relationship.

Physical factors that can affect libido include endocrine issues such as hypothyroidism, the effect of certain prescription medications (for example flutamide), and the attractiveness and biological fitness of one's partner, among various other lifestyle factors.However, the levels of testosterone increase at menopause and this may be why some women may experience a contrary effect of an increased libido.Certain psychological or social factors can reduce the desire for sex.These factors can include lack of privacy or intimacy, stress or fatigue (medical), distraction or depression.Environmental stress, such as prolonged exposure to elevated sound levels or bright light, can also affect libido.Sex drive can also be affected by medical conditions, medications, lifestyle and relationship issues, and age (e.g., puberty).

A person who has extremely frequent or a suddenly increased sex drive may be experiencing hypersexuality, while the opposite condition is hyposexuality.

According to her, testosterone levels rise gradually from about the 24th day of a woman's menstrual cycle until ovulation on about the 14th day of the next cycle, and during this period the woman's desire for sex increases consistently.

The 13th day is generally the day with the highest testosterone levels.

Biologically, the sex hormones and associated neurotransmitters that act upon the nucleus accumbens (primarily testosterone and dopamine, respectively) regulate libido in humans.

Social factors, such as work and family, and internal psychological factors, like personality and stress, can affect libido.

It is this need to conform to society and control the libido that leads to tension and disturbance in the individual, prompting the use of ego defenses to dissipate the psychic energy of these unmet and mostly unconscious needs into other forms. A primary goal of psychoanalysis is to bring the drives of the id into consciousness, allowing them to be met directly and thus reducing the patient's reliance on ego defenses.